Review



hbv capture sequencing  (MyGenostics Inc)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    MyGenostics Inc hbv capture sequencing
    A Map of the CCDC91 gene with <t>HBV</t> DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture <t>sequencing</t> approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Hbv Capture Sequencing, supplied by MyGenostics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hbv+capture+sequencing/ebv+probes/pmc12276357-58-0-6
    Average 90 stars, based on 1 article reviews
    hbv capture sequencing - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinoma"

    Article Title: HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinoma

    Journal: Communications Biology

    doi: 10.1038/s42003-025-08369-1

    A Map of the CCDC91 gene with HBV DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture sequencing approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Figure Legend Snippet: A Map of the CCDC91 gene with HBV DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture sequencing approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.

    Techniques Used: Sequencing, Immunohistochemistry, Staining, Expressing

    Related Articles

    Sequencing:

    Article Title: HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinoma
    Article Snippet: .. HBV capture sequencing was conducted by MyGenostics (Beijing, China). ..

    Article Title: Characterization of hepatitis B virus DNA integration patterns in intrahepatic cholangiocarcinoma.
    Article Snippet: Author affiliations: 1 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2 Department of Emergency, Nanjing First Hospital, Nanjing, Jiangsu, China 3 Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 4 Department of Transplantation, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 5 Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China



    Similar Products

    hbv capture sequencing  (MyGenostics Inc)
    90
    MyGenostics Inc hbv capture sequencing
    A Map of the CCDC91 gene with <t>HBV</t> DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture <t>sequencing</t> approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Hbv Capture Sequencing, supplied by MyGenostics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hbv+capture+sequencing/ebv+probes/pmc12276357-58-0-6
    Average 90 stars, based on 1 article reviews
    hbv capture sequencing - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    sequence-capture probes according to eight types of hbv genome sequences  (MyGenostics Inc)
    90
    MyGenostics Inc sequence-capture probes according to eight types of hbv genome sequences
    A Map of the CCDC91 gene with <t>HBV</t> DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture <t>sequencing</t> approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Sequence Capture Probes According To Eight Types Of Hbv Genome Sequences, supplied by MyGenostics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hbv+capture+sequencing/ebv+probes/pm38529528-43-5-22
    Average 90 stars, based on 1 article reviews
    sequence-capture probes according to eight types of hbv genome sequences - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    hbv capture sequencing  (iGeneTech Bioscience Co Ltd)
    90
    iGeneTech Bioscience Co Ltd hbv capture sequencing
    A Map of the CCDC91 gene with <t>HBV</t> DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture <t>sequencing</t> approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Hbv Capture Sequencing, supplied by iGeneTech Bioscience Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hbv+capture+sequencing/probes+of+hbv+panel/pm37644711-248-7-5
    Average 90 stars, based on 1 article reviews
    hbv capture sequencing - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    sequence capture probes according to eight types of hbv genome sequences  (MyGenostics Inc)
    90
    MyGenostics Inc sequence capture probes according to eight types of hbv genome sequences
    A Map of the CCDC91 gene with <t>HBV</t> DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture <t>sequencing</t> approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Sequence Capture Probes According To Eight Types Of Hbv Genome Sequences, supplied by MyGenostics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hbv+capture+sequencing/ebv+probes/pmc09669288-56-6-23
    Average 90 stars, based on 1 article reviews
    sequence capture probes according to eight types of hbv genome sequences - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    hbv capture sequencing of nhl tissues  (MyGenostics Inc)
    90
    MyGenostics Inc hbv capture sequencing of nhl tissues
    A Map of the CCDC91 gene with <t>HBV</t> DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture <t>sequencing</t> approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Hbv Capture Sequencing Of Nhl Tissues, supplied by MyGenostics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hbv+capture+sequencing/hbv+capture+sequencing+of+nhl+tissues/pm32350851-51-42-47
    Average 90 stars, based on 1 article reviews
    hbv capture sequencing of nhl tissues - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    hbv capture sequencing of nhl tissues  (BGI Shenzhen)
    90
    BGI Shenzhen hbv capture sequencing of nhl tissues
    A Map of the CCDC91 gene with <t>HBV</t> DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture <t>sequencing</t> approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.
    Hbv Capture Sequencing Of Nhl Tissues, supplied by BGI Shenzhen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hbv+capture+sequencing/hbv+capture+sequencing+of+nhl+tissues/pm32350851-51-42-51
    Average 90 stars, based on 1 article reviews
    hbv capture sequencing of nhl tissues - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    A Map of the CCDC91 gene with HBV DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture sequencing approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.

    Journal: Communications Biology

    Article Title: HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinoma

    doi: 10.1038/s42003-025-08369-1

    Figure Lengend Snippet: A Map of the CCDC91 gene with HBV DNA insertion in HCC (n = 17) and NHL (n = 1) tissues. Black arrows indicate HBV integration sites identified through pooled-analysis in HCC. Red arrows represent HBV integration sites detected in HCC samples using our HBV capture sequencing approach. Blue arrows denote HBV integration sites identified in non-Hodgkin lymphoma (NHL) samples from our previous HBV capture sequencing study. B Immunohistochemistry staining showed the protein expression of CCDC91 in 4 HBV capture sequencing HCC tissues. C The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from GSEA cohorts ( GSE36376 : n = 193 in non-tumor, n = 240 in tumor; GSE76427 : n = 52 in non-tumor, n = 115 in tumor). D The mRNA levels of CCDC91 in HCC tissues and non-cancerous liver tissues from TCGA cohort (n = 50 in non-tumor, n = 371 in tumor). E Relative mRNA levels of CCDC91 in HCC cells as determined by qPCR (n = 3 independent biological repeats). F Representative IHC images of CCDC91 in HCC tissues and adjacent paratumor tissues (left) and IHC scores of CCDC91 staining in HCC tissues and non-cancerous liver tissues (right, n = 123). G The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TCGA dataset. H Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TCGA dataset (n = 240). I Multivariate Cox regression analysis of the data from the TCGA dataset revealed that CCDC91 was an independent predictor of OS (n = 120). J The Kaplan–Meier analysis and log-rank test revealed the association of CCDC91 with the overall survival of HCC patients from TMA cohort (n = 123). K Multivariate logistic regression analyses for the associations of CCDC91 expression in HCC patients from TMA cohort (n = 80). Statistical analysis was performed using Student’s t test in ( C , D , E , and F ). Error bars represent the SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.

    Article Snippet: HBV capture sequencing was conducted by MyGenostics (Beijing, China).

    Techniques: Sequencing, Immunohistochemistry, Staining, Expressing